Chalcon

http://www.e-journals.net ISSN: 0973-4945; CODEN ECJHAO E-Journal of Chemistry Vol. 5, No.1, pp. 144-148, January 2008 Synthesis and antimicrobic Activity of just some New Chalcones of 2-Acetyl Pyridine Y. RAJENDRA PRASAD*, P. PRAVEEN KUMAR, P. RAVI KUMAR and A. SRINIVASA RAO University College of Pharmaceutical Sciences, AndhraUniversity, Visakhapatnam-530 003, (A.P), India. dryrp@rediffmail.com authorized 17 July 2007; Accepted 20 September 2007 Abstract: 6 new chalcones were synthesised by express 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic super acid hydroxide solution at room temperature according to Claisen-Schmidt condensation. wholly these compounds were characterised by means of their IR, 1H proton magnetised resonance spectroscopic selective in framingation and microanalyses. The disinfectant activity of these compounds was evaluated by the transfuse plate method. Keywords: Chalcones, Synthesis, healthful activity. Introduction Chalcones either natural or unreal are cognise to exhibit various biologic activities. They pack been heralded to take antioxidant,1-4 antimalarial,5 antileishmanial,6 antiinflammatory,7 antitumor8 and antibacterial activity9.

The presence of a excited ?,?-unsaturated keto function in chalcones is found to be amenable for their antimicrobial activity, which may be altered depending on the suit and military strength of substituent on the aromatic rings. In the usher in communication we report the chemical reaction of 2-acetyl pyridine with different aromatic aldehydes to form chalcones (1-6). The structures of the various synthesized compounds were assign on the basis of elemental analyses, IR and 1H NMR spectral data. These compounds were withal screened for their antimicrobial activity. Experimental Melting points were pertinacious on a capillary melting point implement and are uncorrected. 1 H NMR spectra was recorded in the indicated solvent on Bruker WM four hundred MHz spectrometer with TMS as internal standard. infrared relative frequency spectra were recorded in KBr on...If you lack to get a end essay, order it on our website: Orderessay

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